CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein-tyrosine kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q15303
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q15303
ERBB4_HUMAN
Homo sapiens
Receptor tyrosine-protein kinase erbB-4

PDB Structure

PDB 3BCE
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Mechanism of Activation and Inhibition of the HER4/ErbB4 Kinase.
Qiu, C., Tarrant, M.K., Choi, S.H., Sathyamurthy, A., Bose, R., Banjade, S., Pal, A., Bornmann, W.G., Lemmon, M.A., Cole, P.A., Leahy, D.J.
Structure