CATH Classification

Domain Context

CATH Clusters

Superfamily 1.10.10.2160
Functional Family

Enzyme Information

2.9.1.2
O-phospho-L-seryl-tRNA(Sec):L-selenocysteinyl-tRNA synthase.
based on mapping to UniProt Q6P6M7
O-phospho-L-seryl-tRNA(Sec) + selenophosphate + H(2)O = L-selenocysteinyl-tRNA(Sec) + 2 phosphate.
-!- In archaea and eukarya selenocysteine formation is achieved by a two- step process: EC 2.7.1.164 phosphorylates the endogenous L-seryl- tRNA(Sec) to O-phospho-L-seryl-tRNA(Sec), and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNA(Sec) by Sep-tRNA:Sec-tRNA synthase. -!- Formerly EC 2.9.1.n1.

UniProtKB Entries (1)

Q6P6M7
SPCS_MOUSE
Mus musculus
O-phosphoseryl-tRNA(Sec) selenium transferase

PDB Structure

PDB 3BCB
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and catalytic mechanism of eukaryotic selenocysteine synthase.
Ganichkin, O.M., Xu, X.M., Carlson, B.A., Mix, H., Hatfield, D.L., Gladyshev, V.N., Wahl, M.C.
J.Biol.Chem.