CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family A disintegrin and metalloproteinase with thrombospondin motifs 1

Enzyme Information

3.4.24.-
Metalloendopeptidases.
based on mapping to UniProt Q9UNA0

UniProtKB Entries (1)

Q9UNA0
ATS5_HUMAN
Homo sapiens
A disintegrin and metalloproteinase with thrombospondin motifs 5

PDB Structure

PDB 3B8Z
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2).
Shieh, H.S., Mathis, K.J., Williams, J.M., Hills, R.L., Wiese, J.F., Benson, T.E., Kiefer, J.R., Marino, M.H., Carroll, J.N., Leone, J.W., Malfait, A.M., Arner, E.C., Tortorella, M.D., Tomasselli, A.
J.Biol.Chem.