CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic transduction domain A
Functional Family Sodium/potassium-transporting ATPase subunit alpha

Enzyme Information

7.2.2.13
Na(+)/K(+)-exchanging ATPase.
based on mapping to UniProt P05024
ATP + H(2)O + Na(+)(Side 1) + K(+)(Side 2) = ADP + phosphate + Na(+)(Side 2) + K(+)(Side 1).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- An enzyme from the plasma membrane of animal cells that catalyzes the efflux of three Na(+) and influx of two K(+) per ATP hydrolyzed. -!- It is involved in generating the plasma membrane electrical potential. -!- Formerly EC 3.6.1.37 and EC 3.6.3.9.

UniProtKB Entries (1)

P05024
AT1A1_PIG
Sus scrofa
Sodium/potassium-transporting ATPase subunit alpha-1

PDB Structure

PDB 3B8E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the sodium-potassium pump.
Morth, J.P., Pedersen, B.P., Toustrup-Jensen, M.S., Sorensen, T.L., Petersen, J., Andersen, J.P., Vilsen, B., Nissen, P.
Nature