CATH Domain 3b70A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.180	Quinone Oxidoreductase; Chain A, domain 1
	3.90.180.10	Medium-chain alcohol dehydrogenases, catalytic domain

Domain Context

CATH Clusters

Superfamily	Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family

Enzyme Information

2.3.1.161

Lovastatin nonaketide synthase.

based on mapping to UniProt Q9Y7D0

9 malonyl-CoA + 11 NADPH + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO(2) + 11 NADP(+) + S-adenosyl-L-homocysteine + 6 H(2)O.

-!- This fungal enzyme system comprises a multi-functional polyketide synthase (PKS) and an enoyl reductase. -!- The PKS catalyzes many of the chain building reactions of EC 2.3.1.85, as well as a reductive methylation and a Diels-Alder reaction, while the reductase is responsible for three enoyl reductions that are necessary for dihydromonacolin L acid production.

UniProtKB Entries (1)

Q9Y7D0

LOVC_ASPTE

Aspergillus terreus

Lovastatin nonaketide synthase, enoyl reductase component

PDB Structure

PDB	3B70
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Ames, B.D., Nguyen, C., Bruegger, J., Smith, P., Xu, W., Ma, S., Wong, E., Wong, S., Xie, X., Li, J.W., Vederas, J.C., Tang, Y., Tsai, S.C. Proc.Natl.Acad.Sci.USA