CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.35 |
3',5'-cyclic-GMP phosphodiesterase.
based on mapping to UniProt O76074
Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.
|
UniProtKB Entries (1)
| O76074 |
PDE5A_HUMAN
Homo sapiens
CGMP-specific 3',5'-cyclic phosphodiesterase
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PDB Structure
| PDB | 3B2R |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil.
Mol.Pharmacol.
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