CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial

Enzyme Information

2.5.1.85
All-trans-nonaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific).
based on mapping to UniProt Q5HZ00
Geranylgeranyl diphosphate + 5 isopentenyl diphosphate = 5 diphosphate + all-trans-nonaprenyl diphosphate.
-!- Geranylgeranyl diphosphate is preferred over farnesyl diphosphate as allylic substrate. -!- The plant Arabidopsis thaliana has two different enzymes that catalyze this reaction. -!- SPS1 contributes to the biosynthesis of the ubiquinone side-chain while SPS2 supplies the precursor of the plastoquinone side-chains. -!- Formerly EC 2.5.1.11.

UniProtKB Entries (1)

Q5HZ00
SPS3_ARATH
Arabidopsis thaliana
Solanesyl diphosphate synthase 3, chloroplastic/mitochondrial

PDB Structure

PDB 3AQ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and mechanism of an Arabidopsis medium/long-chain-length prenyl pyrophosphate synthase
Hsieh, F.-L., Chang, T.-H., Ko, T.-P., Wang, A.H.-J.
Plant Physiol.