CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.47.10
Functional Family Chalcone synthase 2

Enzyme Information

2.3.1.211
Bisdemethoxycurcumin synthase.
based on mapping to UniProt Q8LIL0
2 4-coumaroyl-CoA + malonyl-CoA + H(2)O = 3 CoA + bisdemethoxycurcumin + 2 CO(2).
-!- A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyzes the formation of the C(6)-C(7)-C(6) diarylheptanoid scaffold of bisdemethoxycurcumin. -!- Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes, the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment. -!- Formerly EC 2.3.1.n9.

UniProtKB Entries (1)

Q8LIL0
CUS_ORYSJ
Oryza sativa Japonica Group
Bisdemethoxycurcumin synthase

PDB Structure

PDB 3ALE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa
Morita, H., Wanibuchi, K., Nii, H., Kato, R., Sugio, S., Abe, I.
Proc.Natl.Acad.Sci.USA