CATH Classification

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family tRNA wybutosine-synthesizing protein 5

Enzyme Information

1.14.11.42
tRNA(Phe) (7-(3-amino-3-carboxypropyl)wyosine(37)-C(2))-hydroxylase.
based on mapping to UniProt A2RUC4
7-(3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + 2-oxoglutarate + O(2) = 7-(2-hydroxy-3-amino-3-carboxypropyl)wyosine(37) in tRNA(Phe) + succinate + CO(2).
-!- The enzyme is not active with wybutosine.

UniProtKB Entries (1)

A2RUC4
TYW5_HUMAN
Homo sapiens
TRNA wybutosine-synthesizing protein 5

PDB Structure

PDB 3AL6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification.
Kato, M., Araiso, Y., Noma, A., Nagao, A., Suzuki, T., Ishitani, R., Nureki, O.
Nucleic Acids Res.