CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1280.10
Functional Family tRNA (pseudouridine(54)-N(1))-methyltransferase

Enzyme Information

2.1.1.257
tRNA (pseudouridine(54)-N(1))-methyltransferase.
based on mapping to UniProt Q59034
S-adenosyl-L-methionine + pseudouridine(54) in tRNA = S-adenosyl-L- homocysteine + N(1)-methylpseudouridine(54) in tRNA.
-!- While this archaeal enzyme is specific for the 54 position and does not methylate pseudouridine at position 55, the presence of pseudouridine at position 55 is necessary for the efficient methylation of pseudouridine at position 54.

UniProtKB Entries (1)

Q59034
TRMY_METJA
Methanocaldococcus jannaschii DSM 2661
TRNA (pseudouridine(54)-N(1))-methyltransferase

PDB Structure

PDB 3AI9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase
Chen, H.Y., Yuan, Y.A.
J Mol Cell Biol