CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family Subtilisin-like serine protease

Enzyme Information

3.4.21.62
Subtilisin.
based on mapping to UniProt Q5JIZ5
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
-!- Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin. -!- It contains no cysteine residues (although these are found in homologous enzymes). -!- Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). -!- Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16 and EC 3.4.21.14.

UniProtKB Entries (1)

Q5JIZ5
TKSP_THEKO
Thermococcus kodakarensis KOD1
Subtilisin-like serine protease

PDB Structure

PDB 3AFG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of a subtilisin homologue, Tk-SP, from Thermococcus kodakaraensis: requirement of a C-terminal beta-jelly roll domain for hyperstability.
Foophow, T., Tanaka, S., Angkawidjaja, C., Koga, Y., Takano, K., Kanaya, S.
J.Mol.Biol.