CATH Classification

Domain Context

CATH Clusters

Superfamily Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain
Functional Family Mitochondrial succinate dehydrogenase flavoprotein subunit

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt Q0QF01
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

Q0QF01
SDHA_PIG
Sus scrofa
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

PDB Structure

PDB 3AE7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria
Inaoka, D.K., Shiba, T., Sato, D., Balogun, E.O., Sasaki, T., Nagahama, M., Oda, M., Matsuoka, S., Ohmori, J., Honma, T., Inoue, M., Kita, K., Harada, S.
Int J Mol Sci