CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Selenocysteine lyase

Enzyme Information

4.4.1.16
Selenocysteine lyase.
based on mapping to UniProt Q68FT9
L-selenocysteine + reduced acceptor = selenide + L-alanine + acceptor.
-!- Dithiothreitol or 2-mercaptoethanol can act as the reducing agent in the reaction. -!- The enzyme from animals does not act on cysteine, serine or chloroalanine, while the enzyme from bacteria shows activity with cysteine (cf. EC 2.8.1.7).

UniProtKB Entries (1)

Q68FT9
SCLY_RAT
Rattus norvegicus
Selenocysteine lyase

PDB Structure

PDB 3A9X
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase.
Omi, R., Kurokawa, S., Mihara, H., Hayashi, H., Goto, M., Miyahara, I., Kurihara, T., Hirotsu, K., Esaki, N.
J.Biol.Chem.