CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Protein kinase C

Enzyme Information

2.7.11.13
Protein kinase C.
based on mapping to UniProt P41743
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P41743
KPCI_HUMAN
Homo sapiens
Protein kinase C iota type

PDB Structure

PDB 3A8W
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of the PKC-iota kinase domain in its ATP-bound and apo forms reveal defined structures of residues 533-551 in the C-terminal tail and their roles in ATP binding
Takimura, T., Kamata, K., Fukasawa, K., Ohsawa, H., Komatani, H., Yoshizumi, T., Takahashi, I., Kotani, H., Iwasawa, Y.
Acta Crystallogr.,Sect.D