CATH Classification

Domain Context

CATH Clusters

Superfamily Probable tRNA modification gtpase trme; domain 1
Functional Family Aminomethyltransferase

Enzyme Information

2.1.2.10
Aminomethyltransferase.
based on mapping to UniProt P27248
[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH(3).
-!- A component, with EC 1.4.4.2 and EC 1.8.1.4, of the glycine cleavage system, formerly known as glycine synthase. -!- The glycine cleavage system is composed of four components that only loosely associate: the P protein (EC 1.4.4.2), the T protein (EC 2.1.2.10), the L protein (EC 1.8.1.4) and the lipoyl-bearing H protein.

UniProtKB Entries (1)

P27248
GCST_ECOLI
Escherichia coli K-12
Aminomethyltransferase

PDB Structure

PDB 3A8K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism
Okamura-Ikeda, K., Hosaka, H., Maita, N., Fujiwara, K., Yoshizawa, A.C., Nakagawa, A., Taniguchi, H.
J.Biol.Chem.