CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P07948
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P07948
LYN_HUMAN
Homo sapiens
Tyrosine-protein kinase Lyn

PDB Structure

PDB 3A4O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the inhibitor recognition of human Lyn kinase domain
Miyano, N., Kinoshita, T., Nakai, R., Kirii, Y., Yokota, K., Tada, T.
Bioorg.Med.Chem.Lett.