CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.465.60
Functional Family

Enzyme Information

6.3.4.19
tRNA(Ile)-lysidine synthetase.
based on mapping to UniProt Q5L3T3
(tRNA(Ile2))-cytidine(34) + L-lysine + ATP = (tRNA(Ile2))-lysidine(34) + AMP + diphosphate + H(2)O.
-!- The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNA(Ile) at the oxo group in position 2 of cytidine(34). -!- This modification determines both codon and amino acid specificities of tRNA(Ile).

UniProtKB Entries (1)

Q5L3T3
TILS_GEOKA
Geobacillus kaustophilus HTA426
TRNA(Ile)-lysidine synthase

PDB Structure

PDB 3A2K
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase.
Nakanishi, K., Bonnefond, L., Kimura, S., Suzuki, T., Ishitani, R., Nureki, O.
Nature