CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase |
Enzyme Information
| 2.5.1.114 |
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
based on mapping to UniProt O58523
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) = S-methyl- 5'-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe).
-!- The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. -!- This modification is essential for translational reading-frame maintenance. -!- The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).
|
UniProtKB Entries (1)
| O58523 |
TYW2_PYRHO
Pyrococcus horikoshii OT3
TRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase
|
PDB Structure
| PDB | 3A25 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2
Proc.Natl.Acad.Sci.USA
|