CATH Domain 2zznA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	tRNA wybutosine-synthesizing protein 2/3/4

Enzyme Information

2.1.1.228

tRNA (guanine(37)-N(1))-methyltransferase.

based on mapping to UniProt Q58293

S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.

-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q58293

TRM5B_METJA

Methanocaldococcus jannaschii DSM 2661

TRNA (guanine(37)-N1)-methyltransferase Trm5b

PDB Structure

PDB	2ZZN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. Goto-Ito, S., Ito, T., Kuratani, M., Bessho, Y., Yokoyama, S. Nat.Struct.Mol.Biol.