CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.390.30
Functional Family Thioredoxin reductase 1, cytoplasmic

Enzyme Information

1.8.1.9
Thioredoxin-disulfide reductase.
based on mapping to UniProt Q16881
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH.
-!- May be identical to EC 1.8.1.10. -!- Formerly EC 1.6.4.5.

UniProtKB Entries (1)

Q16881
TRXR1_HUMAN
Homo sapiens
Thioredoxin reductase 1, cytoplasmic

PDB Structure

PDB 2ZZ0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Terpyridine-platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1.
Lo, Y.C., Ko, T.P., Su, W.C., Su, T.L., Wang, A.H.J.
J.Inorg.Biochem.