CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P25911
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P25911
LYN_MOUSE
Mus musculus
Tyrosine-protein kinase Lyn

PDB Structure

PDB 2ZV8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structures of the Lyn Protein Tyrosine Kinase Domain in Its Apo- and Inhibitor-bound State
Williams, N.K., Lucet, I.S., Klinken, S.P., Ingley, E., Rossjohn, J.
J.Biol.Chem.