CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family Catechol O-methyltransferase

Enzyme Information

2.1.1.6
Catechol O-methyltransferase.
based on mapping to UniProt P22734
S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol.
-!- The mammalian enzymes act more rapidly on catecholamines such as adrenaline or noradrenaline than on catechols.

UniProtKB Entries (1)

P22734
COMT_RAT
Rattus norvegicus
Catechol O-methyltransferase

PDB Structure

PDB 2ZTH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the Apo and Holo form of rat catechol-O-methyltransferase
Tsuji, E., Okazaki, K., Isaji, M., Takeda, K.
J.Struct.Biol.