CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

PDB 2ZM4
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The importance of CH/pi hydrogen bonds in rational drug design: An ab initio fragment molecular orbital study to leukocyte-specific protein tyrosine (LCK) kinase
Ozawa, T., Tsuji, E., Ozawa, M., Handa, C., Mukaiyama, H., Nishimura, T., Kobayashi, S., Okazaki, K.
Bioorg.Med.Chem.