CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family 6-aminohexanoate-dimer hydrolase

Enzyme Information

3.5.1.46
6-aminohexanoate-oligomer exohydrolase.
based on mapping to UniProt P07061
(1) (N-(6-aminohexanoyl))(n) + H(2)O = (N-(6-aminohexanoyl))(n-1) + 6-aminohexanoate. (2) N-(6-aminohexanoyl)-6-aminohexanoate + H(2)O = 2 6-aminohexanoate.
-!- The enzyme is involved in degradation of nylon-6 oligomers. -!- It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. -!- Activity decreases with the increase of the polymerization number of the oligomer; cf. EC 3.5.1.117 and EC 3.5.2.12.
3.5.1.46
6-aminohexanoate-oligomer exohydrolase.
based on mapping to UniProt P07062
(1) (N-(6-aminohexanoyl))(n) + H(2)O = (N-(6-aminohexanoyl))(n-1) + 6-aminohexanoate. (2) N-(6-aminohexanoyl)-6-aminohexanoate + H(2)O = 2 6-aminohexanoate.
-!- The enzyme is involved in degradation of nylon-6 oligomers. -!- It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. -!- Activity decreases with the increase of the polymerization number of the oligomer; cf. EC 3.5.1.117 and EC 3.5.2.12.

UniProtKB Entries (1)

P07062
NYLC_FLASK
Flavobacterium sp. K172
6-aminohexanoate-dimer hydrolase

PDB Structure

PDB 2ZM0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular design of a nylon-6 byproduct-degrading enzyme from a carboxylesterase with a beta-lactamase fold.
Kawashima, Y., Ohki, T., Shibata, N., Higuchi, Y., Wakitani, Y., Matsuura, Y., Nakata, Y., Takeo, M., Kato, D., Negoro, S.
Febs J.