CATH Classification

Domain Context

CATH Clusters

Superfamily Adenosylhomocysteinase-like
Functional Family

Enzyme Information

3.3.1.1
Adenosylhomocysteinase.
based on mapping to UniProt P9WGV3
S-adenosyl-L-homocysteine + H(2)O = L-homocysteine + adenosine.
-!- The NAD(+) cofactor appears to bring about a transient oxidation at C-3' of the 5'-deoxyadenosine residue, thus labilizing the thioether bond cf. EC 5.5.1.4.

UniProtKB Entries (1)

P9WGV3
SAHH_MYCTU
Mycobacterium tuberculosis H37Rv
Adenosylhomocysteinase

PDB Structure

PDB 2ZJ1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Reddy, M.C., Kuppan, G., Shetty, N.D., Owen, J.L., Ioerger, T.R., Sacchettini, J.C.
Protein Sci.