CATH Classification

Domain Context

CATH Clusters

Superfamily Uracil-DNA glycosylase-like domain
Functional Family Uracil-DNA glycosylase

Enzyme Information

3.2.2.27
Uracil-DNA glycosylase.
based on mapping to UniProt P9WFQ9
Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.
-!- Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. -!- Uracil-DNA glycosylase (EC 3.2.2.27) and double-stranded uracil-DNA glycosylase (EC 3.2.2.28) form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolyzing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalyzing the removal of mis-incorporated uracil from DNA.

UniProtKB Entries (2)

P9WFQ9
UNG_MYCTU
Mycobacterium tuberculosis H37Rv
Uracil-DNA glycosylase
P14739
UNGI_BPPB2
Bacillus phage PBS2
Uracil-DNA glycosylase inhibitor

PDB Structure

PDB 2ZHX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Unique features of the structure and interactions of mycobacterial uracil-DNA glycosylase: structure of a complex of the Mycobacterium tuberculosis enzyme in comparison with those from other sources
Kaushal, P.S., Talawar, R.K., Krishna, P.D.V., Varshney, U., Vijayan, M.
Acta Crystallogr.,Sect.D