CATH Classification

Domain Context

CATH Clusters

Superfamily Zn peptidases
Functional Family Glutaminyl-peptide cyclotransferase

Enzyme Information

2.3.2.5
Glutaminyl-peptide cyclotransferase.
based on mapping to UniProt Q16769
L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH(3).
-!- Involved in the formation of thyrotropin-releasing hormone and other biologically active peptides containing N-terminal pyroglutamyl residues. -!- The enzyme from papaya also acts on glutaminyl-tRNA.

UniProtKB Entries (1)

Q16769
QPCT_HUMAN
Homo sapiens
Glutaminyl-peptide cyclotransferase

PDB Structure

PDB 2ZEP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
A conserved hydrogen-bond network in the catalytic centre of animal glutaminyl cyclases is critical for catalysis.
Huang, K.F., Wang, Y.R., Chang, E.C., Chou, T.L., Wang, A.H.
Biochem.J.