CATH Classification

Domain Context

CATH Clusters

Superfamily ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2
Functional Family Leucine-rich repeat serine/threonine-protein kinase 2

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q5S007
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q5S007
LRRK2_HUMAN
Homo sapiens
Leucine-rich repeat serine/threonine-protein kinase 2

PDB Structure

PDB 2ZEJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
Deng, J., Lewis, P.A., Greggio, E., Sluch, E., Beilina, A., Cookson, M.R.
Proc.Natl.Acad.Sci.Usa