CATH Classification

Domain Context

CATH Clusters

Superfamily Histidine kinase-like ATPase, C-terminal domain
Functional Family Mitochondrial pyruvate dehydrogenase kinase isoform 2

Enzyme Information

2.7.11.2
[Pyruvate dehydrogenase (acetyl-transferring)] kinase.
based on mapping to UniProt Q16654
ATP + [pyruvate dehydrogenase (acetyl-transferring)] = ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate.
-!- Has no activating compound but is specific for its substrate. -!- A mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. -!- Phosphorylation inactivates EC 1.2.4.1. -!- Formerly EC 2.7.1.99.

UniProtKB Entries (1)

Q16654
PDK4_HUMAN
Homo sapiens
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

PDB Structure

PDB 2ZDX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4.
Kukimoto-Niino, M., Tokmakov, A., Terada, T., Ohbayashi, N., Fujimoto, T., Gomi, S., Shiromizu, I., Kawamoto, M., Matsusue, T., Shirouzu, M., Yokoyama, S.
Acta Crystallogr.,Sect.D