CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Prostaglandin reductase 2

Enzyme Information

1.3.1.48
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q8N8N7
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

UniProtKB Entries (1)

Q8N8N7
PTGR2_HUMAN
Homo sapiens
Prostaglandin reductase 2

PDB Structure

PDB 2ZB7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2.
Wu, Y.H., Ko, T.P., Guo, R.T., Hu, S.M., Chuang, L.M., Wang, A.H.J.
Structure