CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase beta-2

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt P20231
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P20231
TRYB2_HUMAN
Homo sapiens
Tryptase beta-2

PDB Structure

PDB 2ZA5
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives
Costanzo, M.J., Yabut, S.C., Zhang, H.-C., White, K.B., de Garavilla, L., Wang, Y., Minor, L.K., Tounge, B.A., Barnakov, A.N., Lewandowski, F., Milligan, C., Spurlino, J.C., Abraham, W.M., Boswell-Smith, V., Page, C.P., Maryanoff, B.E.
Bioorg.Med.Chem.Lett.