CATH Classification

Domain Context

CATH Clusters

Superfamily Farnesyl Diphosphate Synthase
Functional Family

Enzyme Information

2.5.1.-
Transferring alkyl or aryl groups, other than methyl groups.
based on mapping to UniProt Q12051
2.5.1.10
(2E,6E)-farnesyl diphosphate synthase.
based on mapping to UniProt Q12051
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)- farnesyl diphosphate.
-!- Some forms of this enzyme will also use dimethylallyl diphosphate as a substrate. -!- The enzyme will not accept larger prenyl diphosphates as efficient donors.
2.5.1.29
Geranylgeranyl diphosphate synthase.
based on mapping to UniProt Q12051
(2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.
-!- Some forms of this enzyme will also use geranyl diphosphate and dimethylallyl diphosphate as donors; it will not use larger prenyl diphosphates as efficient donors.
2.5.1.1
Dimethylallyltranstransferase.
based on mapping to UniProt Q12051
Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
-!- Will not accept larger prenyl diphosphates as efficient donors.

UniProtKB Entries (1)

Q12051
GGPPS_YEAST
Saccharomyces cerevisiae S288C
Geranylgeranyl pyrophosphate synthase

PDB Structure

PDB 2Z4Y
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation
Chen, C.K.-M., Hudock, M.P., Zhang, Y., Guo, R.-T., Cao, R., No, J.H., Liang, P.-H., Ko, T.-P., Chang, T.-H., Chang, S.-C., Song, Y., Axelson, J., Kumar, A., Wang, A.H.-J., Oldfield, E.
J.Med.Chem.