CATH Classification

Domain Context

CATH Clusters

Superfamily Butyryl-CoA Dehydrogenase, subunit A, domain 2
Functional Family 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component

Enzyme Information

1.14.14.9
4-hydroxyphenylacetate 3-monooxygenase.
based on mapping to UniProt Q5SJP8
4-hydroxyphenylacetate + FADH(2) + O(2) = 3,4-dihydroxyphenylacetate + FAD + H(2)O.
-!- The enzyme from Escherichia coli attacks a broad spectrum of phenolic compounds. -!- The enzyme uses FADH(2) as a substrate rather than a cofactor. -!- FADH(2) is provided by EC 1.5.1.36. -!- Formerly EC 1.14.13.3.

UniProtKB Entries (1)

Q5SJP8
HPAB_THET8
Thermus thermophilus HB8
4-hydroxyphenylacetate 3-monooxygenase oxygenase component

PDB Structure

PDB 2YYK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the Oxygenase Component (HpaB) of the 4-Hydroxyphenylacetate 3-Monooxygenase from Thermus thermophilus HB8
Kim, S.-H., Hisano, T., Takeda, K., Iwasaki, W., Ebihara, A., Miki, K.
J.Biol.Chem.