CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.70.2580
Functional Family tRNA (guanine(37)-N1)-methyltransferase Trm5b

Enzyme Information

2.1.1.228
tRNA (guanine(37)-N(1))-methyltransferase.
based on mapping to UniProt Q58293
S-adenosyl-L-methionine + guanine(37) in tRNA = S-adenosyl-L-homocysteine + N(1)-methylguanine(37) in tRNA.
-!- This enzyme is important for the maintenance of the correct reading frame during translation. -!- Unlike TrmD from Escherichia coli, which recognizes the G(36)pG(37) motif preferentially, the human enzyme (encoded by TRMT5) also methylates inosine at position 37. -!- Formerly EC 2.1.1.31.

UniProtKB Entries (1)

Q58293
TRM5B_METJA
Methanocaldococcus jannaschii DSM 2661
TRNA (guanine(37)-N1)-methyltransferase Trm5b

PDB Structure

PDB 2YX1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5.
Goto-Ito, S., Ito, T., Ishii, R., Muto, Y., Bessho, Y., Yokoyama, S.
Proteins