CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.880
Functional Family GMP synthase [glutamine-hydrolyzing]

Enzyme Information

6.3.5.2
GMP synthase (glutamine-hydrolyzing).
based on mapping to UniProt Q5SI28
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
-!- Involved in the de novo biosynthesis of guanosine nucleotides. -!- An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. -!- The enzyme can catalyze the second reaction alone in the presence of ammonia. -!- Formerly EC 6.3.4.1.

UniProtKB Entries (1)

Q5SI28
GUAA_THET8
Thermus thermophilus HB8
GMP synthase [glutamine-hydrolyzing]

PDB Structure

PDB 2YWC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of GMP synthetase from Thermus thermophilus
Baba, S., Kanagawa, M., Yanai, H., Ishii, T., Kuramitsu, S., Yokoyama, S., Sampei, G., Kawai, G.
To be Published