CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1380 | Methylglyoxal synthase-like domain |
Domain Context
CATH Clusters
| Superfamily | Methylglyoxal synthase-like domain |
| Functional Family | carbamoyl-phosphate synthase [ammonia], mitochondrial |
Enzyme Information
| 6.3.4.16 |
Carbamoyl-phosphate synthase (ammonia).
based on mapping to UniProt P31327
2 ATP + NH(3) + HCO(3)(-) = 2 ADP + phosphate + carbamoyl phosphate.
-!- The enzyme catalyzes the first committed step in the urea cycle. -!- The reaction proceeds via three separate chemical reactions: phosphorylation of hydrogencarbonate to carboxyphosphate; a nucleophilic attack of ammonia on carboxyphosphate yielding carbamate; and the phosphorylation of carbamate forming carbamoyl phosphate. -!- Two moles of ATP are utilized for the synthesis of one molecule of carbamyl phosphate, making the reaction essentially irreversible. -!- The enzyme requires the allosteric activator N-acetyl-L-glutamate. -!- Cf. EC 6.3.5.5. -!- Formerly EC 2.7.2.5.
|
UniProtKB Entries (1)
| P31327 |
CPSM_HUMAN
Homo sapiens
Carbamoyl-phosphate synthase [ammonia], mitochondrial
|
PDB Structure
| PDB | 2YVQ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of MGS domain of carbamoyl-phosphate synthetase from homo sapiens
To be Published
|