CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.58.1360
Functional Family Lysine (K)-specific demethylase 2B

Enzyme Information

1.14.11.27
[Histone H3]-dimetyl-L-lysine-36 demethylase.
based on mapping to UniProt Q9Y2K7
[Protein]-N(6),N(6)-dimethyl-L-lysine + 2 2-oxoglutarate + 2 O(2) = [protein]-L-lysine + 2 succinate + 2 formaldehyde + 2 CO(2).
-!- Of the seven potential methylation sites in histones H3 (K4, K9, K27, K36, K79) and H4 (K20, R3) from HeLa cells, the enzyme is specific for Lys-36. -!- Lysine residues exist in three methylation states (mono-, di- and trimethylated). -!- The enzyme preferentially demethylates the dimethyl form of Lys-36 (K36me2), which is its natural substrate, to form the monomethyl and unmethylated forms of Lys-36. -!- It can also demethylate the monomethyl- but not the trimethyl form of Lys-36.

UniProtKB Entries (1)

Q9Y2K7
KDM2A_HUMAN
Homo sapiens
Lysine-specific demethylase 2A

PDB Structure

PDB 2YU2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for histone demethylation by JHDM1
Han, Z., Liu, P., Gu, L., Zhang, Y., Li, H., Chen, S., Chai, J.
To be Published