CATH Classification

Domain Context

CATH Clusters

Superfamily N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain
Functional Family tRNA (guanine(26)-N(2))-dimethyltransferase

Enzyme Information

2.1.1.216
tRNA (guanine(26)-N(2))-dimethyltransferase.
based on mapping to UniProt O59493
2 S-adenosyl-L-methionine + guanine(26) in tRNA = 2 S-adenosyl-L- homocysteine + N(2)-dimethylguanine(26) in tRNA.
-!- The enzyme dissociates from its tRNA substrate between the two consecutive methylation reactions. -!- In contrast to EC 2.1.1.215, this enzyme does not catalyze the methylation of guanine(27) in tRNA. -!- Formerly EC 2.1.1.32.

UniProtKB Entries (1)

O59493
TRM1_PYRHO
Pyrococcus horikoshii OT3
TRNA (guanine(26)-N(2))-dimethyltransferase

PDB Structure

PDB 2YTZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of tRNA N(2),N(2)-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii
Ihsanawati, Nishimoto, M., Higashijima, K., Shirouzu, M., Grosjean, H., Bessho, Y., Yokoyama, S.
J.Mol.Biol.