CATH Classification

Domain Context

CATH Clusters

Superfamily FAD/NAD(P)-binding domain
Functional Family

Enzyme Information

1.14.13.92
Phenylacetone monooxygenase.
based on mapping to UniProt Q47PU3
Phenylacetone + NADPH + O(2) = benzyl acetate + NADP(+) + H(2)O.
-!- NADH cannot replace NADPH as coenzyme. -!- In addition to phenylacetone, which is the best substrate found to date, this Baeyer-Villiger monooxygenase can oxidize other aromatic ketones (1-(4-hydroxyphenyl)propan-2-one, 1-(4-hydroxyphenyl)propan- 2-one and 3-phenylbutan-2-one), some alipatic ketones (e.g. dodecan- 2-one) and sulfides (e.g. 1-methyl-4-(methylsulfanyl)benzene).

UniProtKB Entries (1)

Q47PU3
PAMO_THEFY
Thermobifida fusca YX
Phenylacetone monooxygenase

PDB Structure

PDB 2YLZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Snapshots of Enzymatic Baeyer-Villiger Catalysis: Oxygen Activation and Intermediate Stabilization.
Orru, R., Dudek, H.M., Martinoli, C., Torres Pazmino, D.E., Royant, A., Weik, M., Fraaije, M.W., Mattevi, A.
J.Biol.Chem.