CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | STEAP2 metalloreductase |
Enzyme Information
| 1.16.1.9 |
Ferric-chelate reductase (NADPH).
based on mapping to UniProt Q4V8K1
2 Fe(II)-siderophore + NADP(+) + H(+) = 2 Fe(III)-siderophore + NADPH.
-!- The enzyme, which is widespread among bacteria, catalyzes the reduction of ferric iron bound to a variety of iron chelators (siderophores), including ferric triscatecholates and ferric dicitrate, resulting in the release of ferrous iron. -!- The enzyme from the bacterium Escherichia coli has the highest efficiency with the hydrolyzed ferric enterobactin complex ferric N-(2,3-dihydroxybenzoyl)-L-serine. -!- Cf. EC 1.16.1.7 and EC 1.16.1.10.
|
UniProtKB Entries (1)
| Q4V8K1 |
STEA4_RAT
Rattus norvegicus
Metalloreductase STEAP4
|
PDB Structure
| PDB | 2YJZ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Crystal Structure of Six-Transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-Binding Site.
J.Biol.Chem.
|