CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O96017
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O96017
CHK2_HUMAN
Homo sapiens
Serine/threonine-protein kinase Chk2

PDB Structure

PDB 2YIT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
Lountos, G.T., Jobson, A.G., Tropea, J.E., Self, C.R., Zhang, G., Pommier, Y., Shoemaker, R.H., Waugh, D.S.
FEBS Lett.