CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.10
Functional Family Chitinase 3-like 1

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt Q9BZP6
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

Q9BZP6
CHIA_HUMAN
Homo sapiens
Acidic mammalian chitinase

PDB Structure

PDB 2YBU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor.
Sutherland, T.E., Andersen, O.A., Betou, M., Eggleston, I.M., Maizels, R.M., van Aalten, D., Allen, J.E.
Chem. Biol.