CATH Classification

Domain Context

CATH Clusters

Superfamily Cupin
Functional Family Lysine-specific demethylase 4A

Enzyme Information

1.14.11.-
With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.
based on mapping to UniProt O75164

UniProtKB Entries (1)

O75164
KDM4A_HUMAN
Homo sapiens
Lysine-specific demethylase 4A

PDB Structure

PDB 2YBK
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Chowdhury, R., Yeoh, K.K., Tian, Y.M., Hillringhaus, L., Bagg, E.A., Rose, N.R., Leung, I.K., Li, X.S., Woon, E.C., Yang, M., McDonough, M.A., King, O.N., Clifton, I.J., Klose, R.J., Claridge, T.D., Ratcliffe, P.J., Schofield, C.J., Kawamura, A.
EMBO Rep.