CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350
PLK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 2YAC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Nms-P937, a 4,5-Dihydro-1H-Pyrazolo[4,3-H]Quinazoline Derivative as Potent and Selective Polo-Like Kinase 1 Inhibitor.
Beria, I., Bossi, R.T., Brasca, M.G., Caruso, M., Ceccarelli, W., Fachin, G., Fasolini, M., Forte, B., Fiorentini, F., Pesenti, E., Pezzetta, D., Posteri, H., Scolaro, A., Depaolini, S.R., Valsasina, B.
Bioorg.Med.Chem.Lett.