CATH Classification

CATH Clusters

Superfamily 2.40.220.20
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P62575
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P62575
NANA_STREE
Streptococcus pneumoniae
Sialidase A

PDB Structure

PDB 2YA5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Streptococcus Pneumoniae Nana Inhibition by Influenza Antivirals Zanamivir and Oseltamivir Carboxylate.
Gut, H., Xu, G., Taylor, G.L., Walsh, M.A.
J.Mol.Biol.