CATH Domain 2y8nB01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.20	Single Sheet
	2.20.70	Ubiquitin Ligase Nedd4; Chain: W;
	2.20.70.100

Domain Context

CATH Clusters

Superfamily	2.20.70.100
Functional Family

Enzyme Information

4.1.1.83

4-hydroxyphenylacetate decarboxylase.

based on mapping to UniProt Q38HX3

(4-hydroxyphenyl)acetate = 4-methylphenol + CO(2).

-!- The enzyme, from the strict anaerobe Clostridium difficile, can also use (3,4-dihydroxyphenyl)acetate as a substrate, yielding 4-methylcatechol as a product. -!- The enzyme is a glycyl radical enzyme.

UniProtKB Entries (1)

Q38HX3

HPDS_CLOSL

Clostridium scatologenes

4-hydroxyphenylacetate decarboxylase small subunit

PDB Structure

PDB	2Y8N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis for a Kolbe-Type Decarboxylation Catalyzed by a Glycyl Radical Enzyme. Martins, B.M., Blaser, M., Feliks, M., Ullmann, G.M., Buckel, W., Selmer, T. J.Am.Chem.Soc.