CATH Classification

Domain Context

CATH Clusters

Superfamily Isopropylmalate Dehydrogenase
Functional Family 3-isopropylmalate dehydrogenase

Enzyme Information

1.1.1.85
3-isopropylmalate dehydrogenase.
based on mapping to UniProt Q5SIY4
(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO(2) + NADH.

UniProtKB Entries (1)

Q5SIY4
LEU3_THET8
Thermus thermophilus HB8
3-isopropylmalate dehydrogenase

PDB Structure

PDB 2Y42
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Atomic Level Description of the Domain Closure in a Dimeric Enzyme: Thermus Thermophilus 3-Isopropylmalate Dehydrogenase.
Graczer, E., Merli, A., Singh, R.K., Karuppasamy, M., Zavodszky, P., Weiss, M.S., Vas, M.
Mol.Biosyst.