CATH Classification
Domain Context
CATH Clusters
| Superfamily | Phosphatidylinositol 3-kinase, accessory domain (PIK) |
| Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta |
Enzyme Information
| 2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt Q8BTI9
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
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UniProtKB Entries (1)
| Q8BTI9 |
PK3CB_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
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PDB Structure
| PDB | 2Y3A |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Mol.Cell
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