CATH Classification

Domain Context

CATH Clusters

Superfamily q2cbj1_9rhob like domain
Functional Family Egl nine homolog 1

Enzyme Information

1.14.11.29
Hypoxia-inducible factor-proline dioxygenase.
based on mapping to UniProt Q9GZT9
Hypoxia-inducible factor-L-proline + 2-oxoglutarate + O(2) = hypoxia- inducible factor-trans-4-hydroxy-L-proline + succinate + CO(2).
-!- Contains iron, and requires ascorbate. -!- Specifically hydroxylates a proline residue in HIF-alpha, the alpha subunit of the transcriptional regulator HIF (hypoxia-inducible factor), which targets HIF for proteasomal destruction. -!- The requirement of oxygen for the hydroxylation reaction enables animals to respond to hypoxia.

UniProtKB Entries (1)

Q9GZT9
EGLN1_HUMAN
Homo sapiens
Egl nine homolog 1

PDB Structure

PDB 2Y34
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
Chowdhury, R., Flashman, E., Mecinovic, J., Kramer, H.B., Kessler, B.M., Frapart, Y.M., Boucher, J.L., Clifton, I.J., McDonough, M.A., Schofield, C.J.
J. Mol. Biol.