CATH Classification

Domain Context

CATH Clusters

Superfamily Homeodomain-like
Functional Family DNA-directed RNA polymerases I, II, and III subunit

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt B8YB63
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

B8YB65
B8YB65_SACSH
Saccharolobus shibatae B12
RNA polymerase subunit 13

PDB Structure

PDB 2Y0S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Archaeal RNA polymerase: the influence of the protruding stalk in crystal packing and preliminary biophysical analysis of the Rpo13 subunit.
Wojtas, M., Peralta, B., Ondiviela, M., Mogni, M., Bell, S.D., Abrescia, N.G.
Biochem. Soc. Trans.